You will need to understand question 3 in More Genetic TIPS before answering this question. A gene that is normally expressed in pancreatic cells was cloned and then subjected to promoter bashing. As...

You will need to understand question 3 in More Genetic TIPS before answering this question. A gene that is normally expressed in pancreatic cells was cloned and then subjected to promoter bashing. As shown here, four regions, labeled A–D, were individually deleted, and then the DNA was transformed into pancreatic cells or into kidney cells.

If we assume that the upstream region has one silencer and one enhancer, answer the following questions:

A. Where are the silencer and enhancer located?

B. Why don’t we detect the presence of the silencer in the pancreatic cells?

C. Why isn’t this gene normally expressed in kidney cells?