You may use all resources available to you to research these questions, but your answers must be yours and yours alone.
Style:
Pretend you are at the front of the class and I have asked you these questions. Imagine how you would say the answer out loud.
Do not quote! You can’t memorize quotes, you’re in front of the class.
Do not cite literature! This isn’t a paper, it’s an answer to a question I’ve asked you.
Each answer should fit in on a
single page
using 12 pt. font (you may delete the question)!
It will Check Through Turnitin
Good Luck!
1.
Discuss the effects of histone modification and DNA modification on transcription. Describe ways in which marks can
activate and repress
transcription for
both types
of modification. For all modifications, describe any known mechanisms of action.
(You must describe a way DNA methylation can activate gene expression to get full credit.)
2.
Compare the repressive effects of chromatin and DNA modifications to the repressive effects of RNAi. Include the following in your answer:
a) a basic overview of RISC and RITS repression
b) mechanisms or effects of RNAi that are similar or related to changes in chromatin
c) mechanisms or effects of RNAi that are unique
(Do not duplicate
explanations
of DNA/histone modifications from Question 1 above. Feel free to reference them. “As with histone acetylation, RNAi acts at . . .”)