write a summary and critical analysis of a clinical study paper. The written assignment has 5 Sections [a)- e) shown below].The chosen clinical study paper is "Long-term b-blocker therapy and clinical...

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write a summary and critical analysis of a clinical study paper. The written assignment has 5 Sections [a)- e) shown below].The chosen clinical study paper is "Long-term b-blocker therapy and clinical outcomes after acute myocardial infarction in patients without heart failure: nationwide cohort study" the paper is attached below.Overall, this assignment involves an evidence-focused, not an opinion-based, assessment.
The assignment structure should have the following Section headings, which are weighted for % assessment as shown. The grading will be based on the criteria detailed below. Given the overall length of 1000 words (±10%), you should allocate the words per Section accordingly.
Section a). Disease mechanisms and treatment challenges (20%). Outline the disease condition and current understanding of mechanisms involved in disease aetiology. Comment on the availability of current treatment options (if any), their limitations and effectiveness. The concluding sentence in this Section should explain how the investigation described in the publication was intended to advance treatment of an aspect the disease condition.
Section b). General characteristics of the study (10%). Provide summary details of the design of the clinical study reported in your paper. Include information about the study type, purpose, structure and approach.
Section c). Outline of methods and important results (20%). Outline the key data findings, summarizing methods used, statistics applied and including details of selective and specific data as supporting information. Ensure that you produce an evidence-based text.
Section d). Critical analysis (30%). Critically analyse the study, assessing whether the design addresses the identified purpose, if the interpretation of findings is fully supported by the data presented, and if any study implementation issues may limit the interpretation.
Section e). Evaluation of translation potential (20%). Assess the possible value of the study in achieving translational health outcomes in cardiac disease. Consider whether findings have limited incremental value or potential to lead to major benefit.




Answered Same DayOct 18, 2021

Answer To: write a summary and critical analysis of a clinical study paper. The written assignment has 5...

Deepika answered on Oct 18 2021
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Section a). Disease mechanisms and treatment challenges (20%). Outline the disease condition and current understanding of mechanisms involved in disease aetiology. Comment on the availability of current treatment options (if any), their limitations and effectiveness. The concluding sentence in this Section should explain how the investigation described in the publication was intended to advance treatment of an aspect the disease condition.
Response: Myocardial infarction is an acute condition where an atherosclerotic plaque builds up in the inner lining of a coronary artery, ruptures causing thrombus formation. Thrombi formation is the major mechanism here in this acute illness. Coronary thrombi exhibit rapid dynamic changes in cell structure and cell composition from onset of pain to the intervention.
Treatment options include a minimally invasive procedure called angioplasty to unblock the arteries that supply blood to the heart, coronary artery bypass graft (CABG) to veins and arteries so the blood can flow around the blockage, a cardiac stent to treat narrowed coronary arteries and medications such as blood thinners, thrombolytics, antiplatelet drugs, beta-blockers, ACE inhibitors, etc.
A disadvantage of angioplasty as compared with CABG is that the artery may narrow again over time. The chance of this happening is lower when stents are used, especially medicine-coated stents. Stents have limitation of use in those with very tight or calcified lesions, seriously depressed left ventricular (LV) function, or renal insufficiency.
In this study, role of beta-blockers was assessed for the treatment of acute myocardial infarction and it was noted that beta-blockers therapy for more than an year reduces the death rate as compared to less than an year or more than 3 years in patients with no heart failure.
Section b). General characteristics of the study (10%). Provide summary details of the design of the clinical study reported in your paper. Include information about...
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