Which one of the following might be the BEST way to measure adherence to a prescribed medication regime? 1. Direct observation of medication administration 2. Evidence of illness complications or...

Which one of the following might be the BEST way to measure adherence to a prescribed medication regime?

1. Direct observation of medication administration

2. Evidence of illness complications or exacerbations

3. Monitoring laboratory values of elements influenced by the medication

4. Questioning the client about his or her medication routine