Which of the following signs would alert the nurse to the possibility of the development of toxicity to methotrexate (Rheumatrex)? 1. Headache, dizziness, and blurred vision 2. Hematuria, hiccoughs,...

Which of the following signs would alert the nurse to the possibility of the development of toxicity to methotrexate (Rheumatrex)?

1. Headache, dizziness, and blurred vision

2. Hematuria, hiccoughs, and jaundice

3. Stomatitis, constipation, and dyspepsia

4. Jaundice, ascites, and edema formation