Which of the following is consistent with a shift to the right of the oxygen-hemoglobin dissociation curve?
A. Increased affinity of hemoglobin for oxygen
B. Decreased P50, or O2 tension that produces 50% hemoglobin saturation
C. Facilitated off-loading of oxygen to peripheral tissues
D. Decreased temperature, increased pH, decreased PCO2, decreased 2,3-DPG
E. CO poisoning
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