Application of Chi-square Application of Chi-square test in analyzing genetic test in analyzing genetic data dataUse of Chi-square test Use of Chi-square test • One dimension of Categorization • One dimension of Categorization • To determine if the observed results • To determine if the observed results deviate from expected frequencies deviate from expected frequencies • Two dimensions of Categorization • Two dimensions of Categorization • To determine if two categorical • To determine if two categorical variables are associated variables are associated • (Chi-square test of association) (Chi-square test of association) •Chi-square test procedures Chi-square test procedures • Set the null hypothesis • Set the null hypothesis • (There is no deviation from expected frequencies or • (There is no deviation from expected frequencies or no association between two categorical variables. ) no association between two categorical variables. ) • Calculate the Chi-square value • Calculate the Chi-square value • Determine the degree of freedom • Determine the degree of freedom • Refer to the Chi-square critical value • Refer to the Chi-square critical value table for corresponding probability table for corresponding probability • Decide whether to reject the null Decide whether to reject the null • hypothesis hypothesis
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