Vasopressin or antidiuretic hormone (ADH) is a peptide hormone synthesized in the a) hypothalamus. This hormone, when present, induces expression of water transport proteins (aquaporins) in the late...

Extracted text: Vasopressin or antidiuretic hormone (ADH) is a peptide hormone synthesized in the a) hypothalamus. This hormone, when present, induces expression of water transport proteins (aquaporins) in the late distal tubule and collecting duct of the kidney to increase water reabsorption. Binding to the receptor triggers an intracellular cyclic adenosine monophosphate (CAMP) pathway. Arrange the following steps of hormone signalling in the proper order by putting 1, 2, 3, etc in the space provided, CAMP activates CAMP-dependent protein kinase (PKA). Recruitment of inactive G-protein made of heterotrimeric subunits which has GDP bound to a-subunit. Conformation change in GPCR. Adenylyl cyclase converts ATP into CAMP. PKA phosphorylates proteins in the cell. A cellular response is seen in the cell. a-subunit with GTP bound activates adenylyl cyclase. Activation of G-protein, thus GDP released an GTP binds to a-subunit. a-subunit of G-protein dissociates from By-dimer. Hormone binding to its G-protein coupled receptor (GPCR). Increase in CAMP concentration, which is the second messenger.