Various studies validate the use of prophylactic antibiotic administration in elective total joint arthroplasty by demonstrating infection rates of less than 1 % compared with 4% with placebo....

Various studies validate the use of prophylactic antibiotic administration in elective total joint arthroplasty by demonstrating infection rates of less than 1 % compared with 4% with placebo.

Preoperative antibiotic therapy must be given several hours or days before surgery to increase its efficacy.