Using the MidTerm, determine HQ and risk, as appropriate, for each chemical and each pathway.
Risk = toxicity x Exposure
HQ (Hazard quotient) = E/RfD
E = Exposure intake
RfD = reference dose
(E andRfD must be in same units)
Given Data Table AirGroundwaterSoilChemicalMax, mg/m3Max, mg/LMax, mg/kgChlorobenzene8.09e-81.10e-26.40Chloroform3.12e-127.60e-34.101,2-Dichloroethane2.40e-82.00e-32.2BEHP8.29e-7.0102.30e2 BEHP-bis-2-ethyl hexyl phthalate (on RBC Table listed under “phthalates“) 1. For each compound, determine if the maximum concentration is above USEPA RBC screening values. Answer As per USEPA RBC screening Value, AirGroundwaterSoilChemicalMax, mg/m3Max, mg/LMax, mg/kgChlorobenzene5.2e+25.3e-22.8e+2Chloroform1.2e-16.1e-53.2e-11,2-Dichloroethane1.87.8e-44.6e-1BEHP1.21.33.9e+1 As per the above table we can see that, 1,2 di-chloro ethane is above the screening level in ground water and soil and BEHP is above careening value in soil. 2. Determine the daily intake for all compounds listed in Table 1 from dermal contact of soils by residents. Note that some chemicals may require evaluation as both carcinogens and non-carcinogens. Answer Exposure factor for 0-1 years and 1-11 are 0.09 and 0.91 respectively. That can be calculated as follows, EF = (F x ED) / AT EF = (365*1) / (11 x 365) EF = 0.09 Similarly, for 1-11 age years EF = 0.91 Now dose can be calculated as, D = Exposure for 0-1 and Exposure for 1-11 D = [(C x A x AF x EF x CF) / BW] + [(C x A x AF x EF x CF) / BW] Here D is Daily Intake, C is concentration of Contaminant in mg/kg EF = exposure Factor, 0.9 and 0.91 BW = body weight CF = Conversion factor, 10-6 A = Total Soil adhered = 210, 525 AF = Bioavailability factor, 0.1 Using the above formula, we can calculate the Daily dose of residents by exposure to soil as, ChemicalAirGround WaterSoilDaily IntakeChlorobenzene8.09E-081.10E-026.41.14016E-05Chloroform3.12E-127.60E-034.17.30415E-061,2-Dichloroethane2.40E-082.00E-032.23.9193E-06BEHP8.29E-070.012.30E+020.000409745 3. Determine the daily intake for all compounds listed in Table 1 from...
Already registered? Login
Not Account? Sign up
Enter your email address to reset your password
Back to Login? Click here