Part A Takehome assignment Q1.A 25-year-old woman, Tzanca, comes to the clinic withbrittle nails and a loss of muscle mass. She is diagnosed with proteindeficiency and told to take a supplement. Part A. Describe the two different ways that enzymes break peptidebonds. For each, please name an example of a peptidase, where it is located andwhat it releases. (2 marks) Part B. If Tzanca's problemsare caused by a fault in a single peptidase, which one is it most likely to be.Explain your rationale. (1 mark). Part C. If the supplement contains single amino acids aswell as dipeptides and tripeptides, how will this help Tzanca? Pleaseinclude details for the absorption from the gut lumen into the enterocyte tothe blood. (2 marks) Q2.Your friend Mr Cinqasept isa 52-year-old man suffering from dyslipidaemia and obesity. Tomanage his condition, his doctor suggests trying a new drug to reduce hisabsorption of ingested fats. Using your knowledge of thefat digestion and absorption (M4L4), please answer the following questions with2-3 sentences for each part. Part A. Describe the processes that take place during fat entry into theenterocytes and subsequent chylomicron formation. (2 marks) Part B. If the new drug prevents fats from moving out of themicelles, explain in detail how this would reduce fat absorption. (1.5marks) Part C. Mr Cinqasept findsthe new drug has the unexpected effect of diarrhoea. Explain whythis is happening and describe two other reasons that could cause the same typeof diarrhoea. (1.5 marks) Q3.Toni Zulli, aged 6, experienced a severeanaphylactic reaction to peanuts. Toni’s mother is distraught in the emergencyroom. She does not understand why this has happened as Tony atepeanuts for the first-time last week. Use your knowledge aboutthe 2 phases of allergic reactions to explain what happened to Toni. Part A. Explain what happens during the sensitisationphase. (2 marks) Part B. Explain what happens during the activation andeffector phase. (2 marks) Part C. Toniis prescribed an EpiPen which contains adrenalin (which isnot an immune modulator). Why does treatment with the EpiPen helphim? (1 mark) Q4. There have been multiplevaccines developed for the COVID-19 pandemic. This has significantlyreduced the death rate. The vaccines made by Pfizerand Moderna are mRNA vaccines. Part A. Please explainwhat an mRNA vaccine is, and what part of the COVID-19virus they target. (1 mark) Part B. How do mRNA vaccinations (likePfizer or Moderna) create immunity in anindividual? (3 marks) Part C. What is the role of abooster vaccination? (1 mark)
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