.
Use the approach of Exercise 9 to compute the distance separating
the human and mouse X chromosomes . (To prevent confusion,
make all segments the same length, so that their projections on the coordinate
axes would be separated by gaps.)
.
GRIMM is the genome rearrangements Web server that computes
optimal rearrangement scenarios relating a source and destination
genome. It is available at http://www-cse.ucsd.edu/groups/bioinformati
cs/GRIMM.
a. Represent genomes x and y4 in as oriented arrows (see Exercise
7). Input x as the source genome and y4 as the destination genome
into GRIMM and run the application. Do you get the same rearrangement
scenario as was actually employed to generate? Do you obtain
the same number of reversals?
b. Check your answer to Exercise 10 by applying GRIMM to the dat.