Answer To: This two-part assignment will allow you to evaluate the role our genes play in the development of...
Riyanka answered on Sep 01 2021
Part I: Evaluating Risk for Disease
1. Potential issues – Non-communicable diseases are occurred by genetic mutation. Any mal sequences have seen in genetic disorders. Combination of both factors that is environmental and genetic default may alter chromosomal structure. There are several diseases can be listed as genetic illness for single inheritance like thalassemias, sickle cell anemia, hemochromatosis etc. From multifactorial inheritance heart diseases, arthritis, diabetes, obesity, alzheimer’s disease, breast cancer with changes in chromosome no. 6,11,14,15 etc. As mitochondrial inheritance with Leber's hereditary optic atrophy (LHON), an eye disease and chromosome abnormalities with Down syndrome. From an article by Maria J., Leah M., Gerhard H.W. M., and Joanna B. W.(2018). that gene play greater or lesser role in all diseases, variation in DNA function can related with many disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients.
2. One of my cousins suffering in type 1diabetes which is insulin dependence diabetes. Diabetes type l is a genetic disorder characterized by increase in blood sugar, insufficient productivity of insulin. Earlier age of childhood or during adolescence most cases are diagnosis.
HLA is human leukocyte antigen that is related with body immunity cell production and help to distinguish body own proteins to virus or bacteria protein that is foreign. HLA gene includes HLA-DQA1, HLA-DQB1, and HLA-DRB1 like as individual or combination of variation associated with developing type - 1 diabetes. Particularly that combination reduces the immune response to beta cell. Diabetes is auto immune disorder with own body tissues or organs are attacked by immune system. For unknown reasons, in people with type 1 diabetes the immune system damages the...