The topic I need to use to create the poster:
"Alpha melanocyte stimulating hormone "
1 A4 page poster
24/05/2021 Peptide mediators poster https://rmit.instructure.com/courses/79108/assignments/520976 1/3 Peptide mediators poster Due Monday by 9:00 Points 100 Submitting a file upload File types pdf Available after 1 Mar at 9:00 Start Assignment COURSE NAME: Principles of Pharmacology COURSE CODE: ONPS2032 ASSIGNMENT TITLE: Peptide mediators poster WEIGHTING: 20% DUE DATE: Monday May 31st, 9am This assessment task supports CLOs 1, 2, and 5. Peptide Mediators assignment - Drugs to affect appetite Introduction Peptide mediators are important physiological regulators. This activity investigates the physiology and pharmacology of peptide mediators in appetite, feeding, and satiety (feeling full). These are complex processes that are regulated by many different neuropeptide mediators. In this exercise, you will investigate the physiology and pharmacology of a peptide mediator that is involved in feeding and satiety. Using this research, you will design a theoretical drug that targets a part of this peptide pathway in order to reduce food intake. You will then prepare a poster that presents the pharmacology of your peptide mediator pathway, and explains how the drug you have designed will interfere with this pathway to reduce food intake. The video below contains a summary of this task. Task Your task is to design a theoretical drug that will act on the physiological pathway (e.g. production, action, termination) of your peptide and reduce food intake (i.e. a new ‘diet pill’). The video lectures on Peptide Mediators by A/Prof Trisha Jenkins (available by week 9) will help you to understand and complete this task. We have selected a short-list of endogenous neuropeptides that can regulate some aspect(s) of feeding and satiety. You will select one of these neuropeptides as the topic for their poster. Peptide selections will open on Canvas in week 8, when you will be able to select a peptide by joining a 'Group' on Canvas. Once you open the 'Groups' section you will see a number of groups, one for each peptide. To select a peptide, simple assign yourself to that group. Please note that there are a limited number of students who can select each peptide – once a 'Group' is full, no other students can select that peptide. Any students who have not selected a peptide on Canvas by Monday May 3rd (week 9) will be allocated a peptide by the course coordinator. All allocations will be final. 1x 0:00 7:00 24/05/2021 Peptide mediators poster https://rmit.instructure.com/courses/79108/assignments/520976 2/3 Please note that the 'Groups' function on Canvas is only being used to manage the selection/allocation of students to a specified peptide. This is an individual assignment, you are NOT expected to work with the other students who have selected/been allocated the same peptide as you. Once you have selected your peptide, you need to do the following: 1) Research your peptide. Your research should focus on two main areas: a) The physiology and pharmacology of your peptide (this includes the peptide production, physiological action, and termination of action). When researching the physiology and pharmacology of your peptide you need to focus on the core pharmacology concepts related to peptide signalling that we have discussed in class. Key things to consider include: How is your peptide synthesized? How is your peptide released? (e.g. What stimulates/inhibits release of your peptide?) What receptors does your peptide interact with? What type of receptors are these? What are the consequences of that interaction? (e.g. Is your peptide an agonist, antagonist, or allosteric modulator? What signalling pathways are affected when your peptide binds to these receptors?) How are the actions of your peptide terminated? b) The role of your peptide in regulating feeding and satiety. Does your peptide increase or decrease food intake? Your primary source for research should be peer-reviewed biomedical science literature which you can search for using PubMed (https://www.ncbi.nlm.nih.gov/pubmed/ (https://www.ncbi.nlm.nih.gov/pubmed/) ). Note: The role of peptide mediators in regulating appetite is an area of active current research, and much of our knowledge in this field is very new. You should not expect to find evidence from clinical studies conducted in humans. You will need to consider information from other types of research such as experimental preclinical studies, animal models, cultured cells, bioinformatics, etc. These different types of research all make important contributions to drug development. 2) After researching your peptide, decide which part of that peptide pathway you will target to create a theoretical drug that will reduce food intake. a) Which part of the peptide pathway will you target? b) How will your drug affect that target? Remember to use your core pharmacology concepts to help you decide this. 3) Create a name for your new drug. 4) Prepare a 1 page poster (A4 size) advertising your new drug. The design of your poster is up to you, however your poster must include the following required elements: a) The name of your new drug (be creative!). b) A brief description of the peptide pathway your drug acts on, and how this peptide affects food intake. c) An explanation of the mechanism of action for your drug. Use a flow chart or diagram to help explain this. d) A catchy marketing slogan to advertise your drug. (For the purposes of this exercise, we will disregard the normal regulations that govern the marketing of pharmaceuticals in Australia!). e) Reference information. You can choose your preferred referencing style, and where you place this information on your poster (although it must be on the same page as the poster, not on the back). There is no minimum number of references. https://www.ncbi.nlm.nih.gov/pubmed/ 24/05/2021 Peptide mediators poster https://rmit.instructure.com/courses/79108/assignments/520976 3/3 Total points: 100 Peptide mediators poster Criteria Ratings Pts 50 pts 20 pts 20 pts 10 pts 5) Submit your poster (as a PDF) via Canvas by 9am Monday May 31 (week 13). RMIT Electronic submission of work for assessment I declare that in submitting all work for this assessment I have read, understood and agree to the content and expectations of the Assessment declaration (https://www.rmit.edu.au/students/student-essentials/assessment-and-exams/assessment/assessment-declaration) . Learning Outcomes Research the physiological pathway of a specific peptide mediator. Apply your knowledge of pharmacology to design a theoretical drug that interacts with this peptide pathway to produce a desired biological effect. Communicate information about your peptide pathway and theoretical drug in a clear, engaging, and scientifically accurate manner. Assessment criteria and feedback mode: Your assignment will be assessed and feedback will be provided via Canvas. The rubric for this assessment can be found below. st Scientific accuracy 50 Pts 100% Peptide pathway information is very clear, comprehensive and accurate. Mechanism of action is very clear and that displays an excellent understanding of the pharmacology involved. 40 Pts 80% Peptide pathway information is clear, comprehensive and accurate. Mechanism of action is very clear and displays a very good understanding of the pharmacology involved. 30 Pts 60% Peptide pathway information is mostly clear and accurate. Mechanism of action is clear and displays good understanding of the pharmacology involved. 20 Pts 40% Peptide pathway information is sometimes inaccurate. Mechanism of action is unclear. 10 Pts 20% Peptide pathway information has many inaccuracies. Mechanism of action is poorly communicated or inaccurate. 0 Pts No marks Peptide pathway information has many inaccuracies. Mechanism of action is poorly communicated or inaccurate. Professional expression and use of language 20 Pts 100% Writing is clear, concise and informative throughout. Professional style and expression used consistently with no errors in spelling, punctuation, or grammar. 16 Pts 80% Writing is generally clear and informative. Professional style and expression used consistently Few minor errors in spelling, punctuation, or grammar. 12 Pts 60% Writing is generally clear. Mostly professional style and expression. Some errors in spelling, punctuation, or grammar. 8 Pts 40% Writing is sometimes unclear. Some use of professional style and expression. Multiple errors in spelling, punctuation, or grammar. 4 Pts 20% Writing is often unclear, with limited use of professional style and expression. Multiple errors in spelling, punctuation, or grammar. 0 Pts No marks Writing is very unclear, with limited use of professional style and expression. Many errors in spelling, punctuation, or grammar. Design, organization and layout 20 Pts 100% Poster has a clear organization, with excellent design and layout. The pictures and graphics are clear and highly relevant. 16 Pts 80% Poster has a clear organization, with very good design and layout. The pictures and graphics are clear and relevant. 12 Pts 60% Poster has a clear organization with generally good design and layout. The pictures and graphics are mostly clear and relevant. 8 Pts 40% Poster lacks a clear organization. Design and layout are unclear or confusing. The pictures and graphics are sometimes unclear or irrelevant. 4 Pts 20% Poster lacks organization. Design and layout are unclear or confusing. The pictures and graphics are often unclear or irrelevant. 0 Pts No marks Poster lacks organization. Design and layout are unclear or confusing. The pictures and graphics are unclear or irrelevant. Content 10 Pts 100% All required elements are present, and clearly and comprehensively communicated. 8 Pts 80% All required elements are present and clearly communicated. 6 Pts 60% Most required elements are present and clearly communicated. 4 Pts 40% Few of the required elements are present and clearly communicated. 2 Pts 20% One (or more) required elements is missing and/or incorrect. 0 Pts No marks Most or all of the required elements are missing and/or incorrect. https://www.rmit.edu.au/students/student-essentials/assessment-and-exams/assessment/assessment-declaration