The posterior pituitary is the main central nervous system site of appetite control. 1. Ghrelin is an orexigenic hormone. 2. Satiety signals include insulin and leptin. 3. Orlistat acts centrally to...

The posterior pituitary is the main central nervous system site of appetite control.

1. Ghrelin is an orexigenic hormone.

2. Satiety signals include insulin and leptin.

3. Orlistat acts centrally to inhibit release of orexigenic neurotransmitters.

4. Vitamin D deficiency can occur with orlistat treatment.

5. Orlistat treatment for obesity should be restricted to individuals with a body mass index (BMI) of more than 30 kg/m².

6. Weight loss is usually sustained after 12 months of orlistat treatment.