The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select all that apply. Drugs should have different mechanisms of action. Each medication should be effective by...

The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select all that apply.

1. Drugs should have different mechanisms of action.


2. Each medication should be effective by itself.


3. Toxicity should concentrate in one body tissue.


4. Overlappping toxicity among the agents should be minimal.


5. Each drug should have the same mechanism of action.