The nurse is reviewing the four clinical phases of investigational drug studies. Place the four phases in the correct order of occurrence. a Studies that are voluntarily conducted by pharmaceutical companies to obtain more information about the therapeutic and adverse effects of a drug. b Studies that involve small numbers of volunteers who have the disease or ailment that the drug is designed to diagnose or treat. c Studies that involve small numbers of healthy subjects who do not have the disease or ailment that the drug is intended to treat. d Studies that involve large numbers of patients who have the disease that the drug is intended to treat; these studies establish the drug’s clinical effectiveness, safety, and dosage range.
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