The nurse is assisting with caring for a client who is receiving a unit of packed red blood cells (PRBCs). The nurse should tell the client that it is most important to report which sign(s)...

The nurse is assisting with caring for a client who is receiving a unit of packed red blood cells (PRBCs). The nurse should tell the client that it is most important to report which sign(s) immediately?

1. Sore throat or earache

2. Chills, itching, or rash

3. Unusual sleepiness or fatigue

4. Mild discomfort at the catheter site