The homozygous loss of a cell cycle regulator or signaling molecule can contribute to malignant transformation. This is most likely for the homozygous loss of A. The Cdk4 protein kinase B. Cyclin E C....

The homozygous loss of a cell cycle regulator or signaling molecule can contribute to malignant transformation. This is most likely for the homozygous loss of A. The Cdk4 protein kinase B. Cyclin E C. E-cadherin D. A MAP kinase E. The transcription factor E2F