Sumatriptan causes chest discomfort in 40% of people as a result of coronary vasoconstriction. 1. Regular use of triptans can cause rebound headache. 2. Pizotifen is used prophylactically and blocks...

Sumatriptan causes chest discomfort in 40% of people as a result of coronary vasoconstriction.

1. Regular use of triptans can cause rebound headache.

2. Pizotifen is used prophylactically and blocks 5-HT2 receptors.

3. Ergotamine is safe to use in ischaemic heart disease.

4. Tricyclic antidepressants and β-adrenoceptor antagonists may be useful in prophylaxis of migraine.