Since 2008 Cargill and Novozymes have collaborated to develop anentirely bio-based route to acrylic acid (2-propenoic acid), which is the basis for production of the hugely important acryl-based...

Since 2008 Cargill and Novozymes have collaborated to develop anentirely bio-based route to acrylic acid (2-propenoic acid), which is the basis for production of the hugely important acryl-based polymers. Central to their effort is to produce 3-hydroxy propionic acid (see Fig.2.1b), which by dehydration of the alcohol gives acrylic acid. Based on two major publications, Straath of et al. (2005) and Henry et al. (2010),you are required to review the research that within less than a decade has led to identification of the best metabolic routes to 3-hydroxy propionic acid, one of the projected platform chemicals in Werpy and Petersen(2004).A thorough study of this problem will teach you how front-line biotech companies use all the suggestions discussed in Sect.2.4.3for strain development, and of pathway engineering in particular.