Red blood cells are normally circular in shape. Sickle cell anemia is a disorder that affects the shapes red blood cells causing them to be sickleshaped (like a crescent moon). Beta hemoglobin...

Red blood cells are normally circular in shape. Sickle cell anemia is a disorder that affects the shapes red blood cells causing them to be sickleshaped (like a crescent moon). Beta hemoglobin normally consists of a chain of 147 amino acids (441 base pairs of DNA). In patients with sickle cell anemia, the beta hemoglobin still has 147 amino acids, yet one amino acid is different. The table below shows a section of the amino acid sequence : Based on the data provided of amino acid sequences and the shape difference between normal red blood cells and those with the sickle cell mutation , which of the following interpretations of data best explains these differences?

Extracted text: acid sequence: Based on the data provided of armino acid sequences and the shape difference between normal red blood cells and those with the sickle cell mutation, which of the following interpretations of data best explains these differences?* 1. 3 4. Normal Amino Acid Thr Pro Glu Glu Lys Sequence Sickle Cell Amino Acid Thr Pro Val Glu Lys Sequence An insertion mutation in the DNA caused the difference found in amino acid 3, and the gene will be longer than normals. A deletion mutation in the DNA sequence caused the difference found in amino acid 3, and the gene will be shorter than normal. A substitution in the DNA sequence caused the difference in amino acid 3, other substitutions may have occurred in order to complete the drastic shape change. A single substitution in the DNA sequence caused the difference in amino acid 3, which caused the shape change. 5.


Extracted text: O A virus inserts nine base pairs into a lung cell of an elderly man. Red blood cells are normally circular in shape. Sickle cell anemia is a disorder that affects the shapes of red blood cells causing them to be sickle-shaped (like a crescent moon). Beta hemoglobin normally consists of a chain of 147 amino acids (441 base pairs of DNA). In patients with sickle cell anemia, the beta hemoglobin still has 147 amino acids, yet one amino acid is different. The table below shows a section of the amino acid sequence: Based on the data provided of amino acid sequences and the shape difference between normal red blood cells and those with the sickle cell mutation, which of the following interpretations of data best explains these differences? * 3 4 Pro Glu Normal Amino Acid Sequence Thr Glu Lys Sickle Cell Amino Acid Sequence Thr Pro Val Glu Lys An insertion mutation in the DNA caused the difference found in amino acid 3, and the aene will be longer than normals