Question 5. Three drugs exhibit the following properties. Clearance (cl) and fraction unbound (fu) are calculated based on plasma data. If any of the three drugs is being overdosed, is it possible...

Extracted text: Question 5. Three drugs exhibit the following properties. Clearance (cl) and fraction unbound (fu) are calculated based on plasma data. If any of the three drugs is being overdosed, is it possible then to accelerate the excretion by administering diuretics? Is so which of the three drugs in the table is relevant, and justify/motivate your answer! Renalt CL (mL/min) Drug Teofyllin Total CL (mL/min) fu 45 0.45 Gentamicin 110 110 0,9 Cefalexin 300 300 0,85 The answer is provided down below, but I don't understand it. How do we know this, how was it solved? Please explain thoroughly. Answers: Gentamicin and Cefalexin is excreted majorly via urine, in these cases diuretics can accelerate the excretion in case of overdose.