Question XXXXXXXXXXwords). Explain the structural and functional changes that occur in the kidneys as chronic kidney disease progresses through the stages 1 to 5. Question XXXXXXXXXXwords) Discuss two...

Question 1. (500 words).

Explain the structural and functional changes that occur in the kidneys as chronic kidney disease progresses through the stages 1 to 5.
Question 2 (200 words)

Discuss two nursing strategies used to manage stage 5 chronic kidney disease and provide         rationales for these strategies.


Question 3.  (300 words)
Calcitriol (Rocaltrol) and epoetin alfa are used in the management of chronic kidney disease.
a)    Explain the mode of action of each of these drugs (calcitriol and epoetin alfa) relating to the underlying pathogenesis


b)    Relating your answer to the pharmacology of the two drugs, discuss nursing implications including how you will monitor and respond to adverse effects and how you will evaluate the therapeutic effect.