Question 1 (20 Marks) From the case study it can be seen that David’s symptoms of depression have increased over a three month period. a) Outline the signs and symptoms of a severe depressive episode...

Question 1 (20 Marks) From the case study it can be seen that David’s symptoms of depression have increased over a three month period.   a) Outline the signs and symptoms of a severe depressive episode (ICD10 diagnosis F32.2 severe depressive episode without psychotic symptoms). b) Outline the pathophysiology of depression.  In your answer discuss how abnormal neurotransmitter function relates to the symptoms of depression.  c) From the case study identify biological factors that may have contributed to David’s depression. d) Provide two different medications to treat David’s depression.  For each medication provide two side effects and the biological reason for each side effect.
Question 2 (15 marks) David has been admitted to hospital in an intoxicated state (due to alcohol). a) Outline the effects of alcohol on the adult brain (be sure to include specific neurotransmitter pathways in your answer). b) David is likely to go into alcohol withdrawal during his hospital stay.  Describe the pathophysiology of alcohol withdrawal. c) Describe the nursing management of alcohol withdrawal in the hospital setting.
Question 3 (20 marks) Using at least 10 recent peer reviewed articles (published in journals from 2012 2017) discuss the biological link between alcohol and depression. (Biological factors include genetics, brain dysfunction, changes in neurotransmitter pathways, vitamin deficiencies etc).