Computers & Operations Research 37 (2010) 1381--1388 Contents lists available at ScienceDirect Computers&OperationsResearch journal homepage: www.elsevier.com/locate/cor InvestigationofanewGRASP-basedclusteringalgorithmappliedtobiologicaldata * MariáC.V.Nascimento ,FranklinaM.B.Toledo,AndréC.P.L.F.deCarvalho Instituto de Ciências Matemáticas e de Computação, Universidade de São Paulo, Caixa Postal 668, São Carlos-SP, CEP 13560-970, Brazil ARTICLE INFO ABSTRACT Available online 5 March 2009 A large amount of biological data has been produced in the last years. Important knowledge can be extracted from these data by the use of data analysis techniques. Clustering plays an important role in Keywords: data analysis, by organizing similar objects from a dataset into meaningful groups. Several clustering Clustering algorithms have been proposed in the literature. However, each algorithm has its bias, being more ade- GRASP quate for particular datasets. This paper presents a mathematical formulation to support the creation of Gene expression data consistent clusters for biological data. Moreover, it shows a clustering algorithm to solve this formulation Bioinformatics that uses GRASP (Greedy Randomized Adaptive Search Procedure). We compared the proposed algorithm with three known other algorithms. The proposed algorithm presented the best clustering results con- firmed statistically. © 2009 Elsevier Ltd. All rights reserved. applied to several domains, like natural language processing [2], 1. Introduction galaxy formation [3] and image segmentation [4]. Surveys and reviews on clustering algorithms and their application to different In the last years there has been a considerable growth of the domains can be found in [5,6]. In particular, a large number of ex- amount of biological data available in several domains. Two of these periments using clustering algorithms to group biological data have domains are proteomics, which studies properties found in proteins, been...
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