Osmolarity, temperature, bile salts, and other environmental signals regulate the production of V. cholerae virulence factors. Name the key transcriptional regulatory systems responsible for toxin...

Osmolarity, temperature, bile salts, and other environmental signals regulate the production of V. cholerae virulence factors. Name the key transcriptional regulatory systems responsible for toxin production found in V. cholerae. Where are they located in the cell? What roles do these proteins play in the regulation of cholera toxin and the Tcp pilus?