Option 1 In the United States, the sickle-cell allele is carried by approximately 1 in 12 people of African ancestry. The sickle-cell allele is expressed in hemoglobin , the molecule that carries...

Option 1

In the United States, the sickle-cell allele is carried by approximately 1 in 12 people of African ancestry. The sickle-cell allele is expressed inhemoglobin, the molecule that carries oxygen in red blood cells.

Sickle-cell disease(also called sickle-cell anemia) is the most common genetic disorder among people of African descent. In this disease, hemoglobin molecules clump together in long fibers, forcing the red blood cells—which are normally round—into long shapes that look like sickles. These sickle-shaped red blood cells tend to get stuck in capillaries, blocking blood flow to cells, tissues, and even entire organs.

Sickle-cell traitis a related condition, although people have few (if any) harmful symptoms. People with this condition actually have a heightened resistance to malaria, a disease that has killed millions.
In this lab activity, you will act as a genetic counselor and help parents determine their likelihood of having children with sickle-cell disease.

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Complete the steps of the scientific method for your lab option choice. Use these headings in your paper, please.


Purpose:

State the purpose of the lab.

Introduction:

This is an investigation of what is currently known about the question being asked. Use background information from credible references to write a short summary about concepts in the lab. List and cite references in APA style.

Hypothesis / Predicted Outcome:

An hypothesis is an “educated guess.” Based on what you have learned and written about in the Introduction, state what you expect to be the results of the lab procedures.

Methods:

Summarize the procedures that you used in the lab.
The Methods section should also state clearly how data (numbers) were collected during the lab; these will be reported in the Results/ Outcome section.

Results/Outcome:

Provide here any results / data that were generated doing the lab procedure.

Discussion/Analysis:

In this section, state clearly whether you obtained the expected results, and the outcome was as expected. Note: You can use answers to any multiple choice or essay questions you filled out in the lab to help you discuss the results and what you learned.
Provide references in APA format. This includes a reference list and in-text citations for references used in the Introduction section.
Give your paper a title and number and identify each section as specified above. Although the hypothesis will be a one sentence answer, the other sections will need to be paragraphs to adequately explain your experiment.
Submit your assignment as a MS Word document.

For assistance with your assignment, please use your text, Web resources, and all course materials.


What percentage of the F₁

offspring have sickle-cell trait, sickle-cell disease, and normal blood?

The percentage of the F1 offspring has 0 percentage of sickle -cell trait,0 percentage of sickle -cell disease and 1 percentage normal blood.

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Part B


What does this result suggest about the pattern of inheritance of sickle-cell disease and sickle-cell trait?

My suggest about the pattern of inheritance of sick-cell disease and sickle-cell trait is that neither parent has neither one because they both have normal blood for the test.

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Part C


How would you counsel this couple about their would-be offspring? What about their offspring’s offspring?

I would get both parent together and show them a copy of the lab report and go over it with them.
To ensure the couple that they have no sickle-cell trait.

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Part D


Complete the three Punnett squares below to illustrate how likely it would be for this couple’s children (who are all carriers of the sickle-cell allele) to produce offspring with sickle-cell disease or sickle-cell trait. (A

represents the normal allele;

S

represents the sickle-cell allele.)






After completing the Punnett squares in Part D, try each cross in the Genetics Lab Room.

For Scenario 1, set the parents’ alleles according to the information provided. Then, set the number of offspring to 6 and click theCrossbutton repeatedly until these parents have produced about 100 offspring. Record the results. Repeat step 4 for Scenario 2 and Scenario 3. Record the results.

Completed


Part E


What percentage of the offspring in each scenario would have sickle-cell disease? What percentage would have sickle-cell trait?

In scenario 1 have 50% and would have the sickle -cell disease, scenario 2 would have 25% with the sickle -cell trait.

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Part F -Think It Over
It’s harmful to have two sickle-cell alleles, but in a region where malaria is prevalent, having one sickle-cell allele can be beneficial.
Review the phenotype breakdown of the offspring in each of the three scenarios above.

Which phenotype is most common overall? Explain how a population in a region affected by malaria could derive more benefit than harm from the presence of the sickle-cell allele.

Yes because some can cause by prevailing alleles for genes. It depends on the situation there could be more than two alleles within the people.

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