סמינריון בוגר- הנחיות למורים ולתלמידים:FROM THE UNIVERCITY Graduate seminar - instructions for teachers and students:Student guide for graduate seminar work:• The length of the work is 5...

Non-viral gene therapy in the CNS (central nervous system) the assignment about





nanomedicine





סמינריון בוגר- הנחיות למורים ולתלמידים: FROM THE UNIVERCITY Graduate seminar - instructions for teachers and students: Student guide for graduate seminar work: • The length of the work is 5 single-spaced pages, not including the list of cited literature. • The order of the chapters in the seminar will be as follows: • Introduction - methods - results - discussion - conclusions - literature list • A list of references must be written according to the convention in the field of research in which he is engaged the seminary. • For example: Arnesano, F.; Scintilla, S.; Natile, G., Interaction between platinum complexes and a methionine motif found in copper transport proteins. Angew. Chemie - International Edition 2007, 46, (47), 9062-9064. Title of seminar: Non-viral gene therapy in the CNS (central nervous system) MY NOTES Introduction 1 or 2 pages 1.what is gene therapy in general (you can take this general information from the article gene therapy , viral pdf + Non Viral Vectors in Gene Therapy- An Overview NOT NECCERLY NEED TO USE THE WHOLE ARTICLE – YOU CAN TAKE WHAT IS NEEDED 2.viral virus vs. non-viral (the advantages and disadvantages of both – and why is non-viral virus delivery is better that the viral virus delivery at gene therapy (you can take this general information from the article gene therapy ,viralpdf + Non Viral Vectors in Gene Therapy- An Overview also its written in Nanodiamond….. ) main article for this work assignment) or for viral vectors you can use this paragraph or just use from the main article(my seminar work about the non-viral. Also, I need to mention “shortly “the viral vector delivery and why the non viral is better – and the you can write about the non- viral extensively) Viral vector is the most effective means of gene transfer to modify specific cell type or tissue and can be manipulated to express therapeutic genes. Several virus types are currently being investigated for use to deliver genes to cells to provide either transient or permanent transgene expression. These include adenoviruses (Ads), retroviruses (γ-retroviruses and lentiviruses), poxviruses, adeno-associated viruses, baculoviruses, and herpes simplex viruses. The choice of virus for routine clinical use will depend on the efficiency of transgene expression, ease of production, safety, toxicity, and stability. This chapter provides an introductory overview of the general characteristics of viral vectors commonly used in gene transfer and their advantages and disadvantages for gene therapy use. 3.to continue writing about -non viral gene therapy in general (because the assignment about it) you can use the articles that I’ve mentioned it before and this article Non-viral gene therapy: Gains and challenges of non-invasive administration methods - methods - results – discussion (3or 4 pages)- the most important thing is to write about the research article 4. to talk about one methods of non-viral gene therapy in the CNS(I’ve found an article about Nanodiamond -cationic noisome they used this method to deliver to the CNS by the non-viral. )main article( you can use this article)main article(Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases - its important to read and write about this article and to take all of the informations - but the other articles you can take the information that you need - and conclusion of the research article and non viral gene delivery in theCNS I think that will help you to understand the assignment more:- this picture is about--- ,a delivery methods (viral and non-viral ) to deliver DNA into the CNS I’ve found(not given by the teacher- its self-work) those article that I mentioned above . the most important thing the order of the assignment Introduction - methods - results - discussion - conclusions - literature list that the university request WHICH YOU CAN USE MAIN ARTICLE Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases This work-assignment is important to me so – if you don’t understand - please feel free to ask me ….