Natural History of Disease and Relationship to Laboratory Testing Due Aug 6, 11:58 pm Objective: 1) Describe natural history of disease in biological terms, including pre-pathogenesis and pathogenesis...

Natural History of Disease and Relationship to Laboratory Testing Due Aug 6, 11:58 pm Objective: 1) Describe natural history of disease in biological terms, including pre-pathogenesis and pathogenesis phases (see pg 98-99 Friis).  2) Use knowledge of the progression of infectious disease, to incorporate concepts of sensitivity and specificity in clinical testing (this is similar to sensitivity and specificity of screening tests but the tests and reasons for testing are different) This paper has two parts. Part A – a description of the disease, and Part B – a description of the diagnostic test. Although there are specific questions that you must answer, write this as a paper and not as a Q&A. Remember to use citations for any idea that is NOT yours, and to add a reference list at the end. Also, use headings for your paragraphs to aid your writing. Look at the rubric (next page) that will be used to grade your paper and make sure all of the elements are in your paper.   Part A: First, choose a disease with a viral, bacteria, fungal or parasitic etiology that has a Laboratory test that MUST be used for diagnosis.   1.   Describe the pre-pathogenesis stage of the disease - a. Are there changes in biological function? b. Are there changes that you can detect before there is a pathogenesis stage of the disease? (hint͓- look for articles/book chapters that identify the incubation period of the illness – that is often synonymous with the pre-pathogenesis phase). 2.   Next identify the symptoms that arrive with the pre-pathogenesis phase of the illness. 3.   Describe the usual outcome of the illness– with and without treatment. 4.   Finally – is there a best time to provide treatment? At the pre-pathogenesis stage, during pathogenesis, another time? Why or why not? 5.   Provide references for all of your answers (references should be no older than 5 years)   Part B:  Identify the laboratory tests used to confirm the diagnosis of the disease. List all of the tests available (if there are more than one) 1.   Identify the specificity and sensitivity of each test. 2.   Explain what those numbers tell you about whether or not the patient actually has the disease 3.   For each identified laboratory test – is there an optimum time in the progression of the disease when testing will provide the most accurate answer? 4.   Based on your analysis, which test would be the “best” test to use? 5.   Provide references for all of your answers. No Longer than 6 pages. Double-spaced.   Natural History of Disease and Relationship to Laboratory Testing  Grading Rubric   Poss. Pts Awarded Pts Part A     1)    Accuracy of pre-pathogenesis description  10   2)    Accuracy of pathogenesis description 10   3)    Accuracy of outcomes 15     Part B     1)    Appropriate lab tests chosen   10   2)    Accurate explanation of sensitivity in relation to each test   10   3)    Accurate explanation of specificity in relation to each test 10   5)    Explanation of which test is the “best” for this dx 15       1) Use APA guidelines, no more than 6 pages 10 2) Current references (past 5 years) 10 TOTAL PTS 100     Comments: