MPTP is a toxin that can be unintentionally synthesized in the illicit manufacturing of opioid drugs . MPTP is selectively taken up by the dopaminergic neurons of the substantia nigra, where its active form causes neuronal death. Cases have been reported of opioid users self-administering MPTP contaminate and developing a severe acute-onset PD. A patient developing this type of toxin-mediated PD will have symptoms resulting from altered activity in which set of brain areas?
A. Substantia nigra reticulata, caudate, putamen, cerebellum
B. Substantia nigra reticulata, striatum, internal segment of the globus pallidus, motor cortex
C. Substantia nigra reticulata, putamen, ventrolateral thalamus, motor cortex
D. Substantia nigra compacta, striatum, internal segment of the globus pallidus, ventrolateral thalamus
E. Substantia nigra compacta, striatum, internal segment of the globus pallidus, cerebellum