Manipulation of the activity of an enzyme Ei in a metabolic pathway reveals that it has a flux control coefficient of 0.15 under physiological conditions. Its elasticity towards the product Si of its...

Manipulation of the activity of an enzyme Ei in a metabolic pathway reveals that it has a flux control coefficient of 0.15 under physiological conditions. Its elasticity towards the product Si of its reaction is found to be −0.25 under the same conditions. The next enzyme Ej in the pathway cannot be directly manipulated, and so its control coefficients cannot be directly measured. However, studies with the purified enzyme indicate that it has an elasticity of 0.2 towards its substrate Si under physiological conditions. Assuming that Si has no significant interactions with any other enzymes in the pathway, estimate the flux control coefficient of E