Major Essay A common theme through the unit has been the controversial or conflicting findings and their impact on the understanding of neuroendocrinology. Using material from lectures, journal club...

Major Essay A common theme through the unit has been the controversial or conflicting findings and their impact on the understanding of neuroendocrinology. Using material from lectures, journal club sessions and other sources explain the nature of one such case and how it has contributed or clouded the scientific understanding of neuroendocrinology. In your essay: Describe the nature of the problem being addressed by the animal or cell biology model. Using specific examples explain how the model/s chosen helped tackle the problem. Outline the information gained through use of the model and explain why this knowledge was controversial (ie. compared to previous research). Discuss the limitations and/or advantages to the use of the model for understanding the problem. Maximum length of 2500 words (does not include references). Harvard referencing required. Submission is through Turnitin Controversial questions in neuroendocrinology GnRH: Is the production of LH pulses intrinsic to GnRH neurons or reliant on an external pulse generator? Are GABAergic afferents to GnRH neurons inhibitory or excitatory? Metabolism: Is the gut peptide PYY an inhibitor of food intake? Is obesity a result of food addiction? Kisspeptin: Is kisspeptin really critical for the onset of puberty? Does the satiety hormone leptin signal directly to kisspeptin neurons? Does kisspeptin play a significant role in energy balance and obesity? GnIH: Is GnIH really a gonadotropin inhibitory hormone? Does it play any significant role in mammals?