Instructions: Read the following cases and answer the questions accordingly. Type your answer after each question. Case 2 A 28-year-old man presents to the physician’s office for evaluation of a rash...

Instructions: Read the following cases and answer the questions accordingly. Type your answer after each question.

Case 2

A 28-year-old man presents to the physician’s office for evaluation of a rash on his chest. He started with one oval-shaped purplish area that he thought was a bruise but has subsequently developed multiple new lesions. The growths don’t hurt, itch, or bleed, but he continues to get new ones, and the existing ones are getting larger. He has never had anything like this before, has no history of allergies and denies exposure to any new medications, foods, lotions, or soaps. His past medical and family histories are unremarkable. His review of systems is significant for a 15-lb weight loss in the past 2 months, approximately 6 weeks of diarrhea, and a 3-week history of a sore throat. On examination, he is a thin but generally well appearing male. His vital signs are normal. Examination of his pharynx shows thick white plaques on the posterior pharynx and soft palate. On the skin of his chest are multiple oval-shaped purple or brown macules. They are firm on palpation and vary in size from 0.5 to 4 cm in length. Several of them appear to be growing together into larger, confluent plaques. You perform a punch biopsy of one of the lesions. In 5 days you get the pathology report with the diagnosis of Kaposi sarcoma.

1. With what virus is this patient likely infected?

2. What specific cell types are most commonly infected with this virus? What cell surface receptor is the binding site of this virus?

3. What serologic testing is most frequently performed to make this diagnosis?