In Europe, the frequency of the CF2 allele causing the recessive autosomal disease cystic fibrosis is about 0.04. Cystic fibrosis causes death before reproduction in virtually all cases. a. Determine...

In Europe, the frequency of the CF2 allele causing the recessive autosomal disease cystic fibrosis is about 0.04. Cystic fibrosis causes death before reproduction in virtually all cases.

a. Determine values of fitness ( w ) and of the selection coefficient ( s ) for the unaffected, carrier, and affected genotypes.

b. Determine the average fitness at birth of the population as a whole with respect to the cystic fibrosis trait (w) and the expected change in allele frequency over one generation (Dq ) when measured at the birth of the next generation.

Now suppose that the mutation rate from CF
⁺
to CF^--
alleles is 1 * 10
^--6 .

c. What is the expected evolutionary equilibrium frequency (qˆ) of the CF^--
allele? Is this larger or smaller than the observed frequency?

d. Without changing the value of s for the CF^--/ CF^--
genotype you calculated in part a , propose an explanation that might resolve the discrepancy between the observed and expected frequencies of the CF^--
allele you noted in part c .