In Activity 2.7 you wrote code to determine the dose escalation pattern for a phase I clinical trial of a new cytotoxic drug. Recall that the dose escalation pattern was determined by increasing the...

In Activity 2.7 you wrote code to determine the dose escalation pattern for a phase I clinical trial of a new cytotoxic drug. Recall that the dose escalation pattern was determined by increasing the initial dose by 67%, then by 50%, then by 40% and subsequently by 33% each time.A common way of applying the dose escalation pattern is the “3 + 3 rule”. With this approach, the trial proceeds using cohorts of 3 patients in the following way: