In 1984, Barry Marshall took a unique approach to fulfill Koch’s postulates. He drank a culture of the bacterium H. pylori and developed a mild case of gastritis, although another volunteer developed...

In 1984, Barry Marshall took a unique approach to fulfill Koch’s postulates. He drank a culture of the bacterium H. pylori and developed a mild case of gastritis, although another volunteer developed a more severe case of gastritis. He and his mentor, Robin Warren, won the Nobel Prize in Physiology or Medicine in 2005 for their discovery of the role of H. pylori in the pathogenesis of gastritis and peptic (stomach and duodenal) ulcers. Given that 80% of peptic ulcer disease cases are known to be associated with H. pylori infection, briefly describe how each of Koch’s postulates is fulfilled for the link between H. pylori and peptic ulcer disease. What modern approaches can be taken to help satisfy Koch’s postulates for this case?