In 1976, the Bellevue Stratford Hotel in downtown Philadelphia hosted a convention of members of the American Legion. During the convention, 221 Legionnaires developed a new form of pneumonia, and 34 people died. Infectious disease specialists working for the CDC were sent to Philadelphia to identify the cause of this new, mysterious illness, which, not surprisingly, was subsequently named Legionnaire’s disease. Using Koch’s postulates, list the steps that those specialists had to take to complete their assignment. Briefly explain the significance of each step. The specialists understood that it is not always possible to follow Koch’s postulates to the letter. List at least two problems that they might have faced in attempting to fulfill Koch’s postulates as they embarked on their quest to identify the causative agent of this new illness.
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