Imagine you make a mutation to an enzyme and determine that you have strongly stabilized the ES complex. the stability of the EX ‡ is unchanged. Draw the expected reaction free energy coordinate for...


Imagine you make a mutation to an enzyme and determine that you have strongly stabilized the ES complex.  the stability of the EX
is unchanged.


Draw the expected reaction free energy coordinate for the original enzyme (solid line) and the mutated enzyme (dashed line).


Do you expect this mutation to have an effect on the rate of product formation? If so, what is the effect?



Jun 11, 2022
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