How does irinotecan act as an antineoplastic drug?
A. It alkylates base pairs and blocks DNA polymerase.
B. It blocks conversion of ribonucleotide to deoxyribonucleotide.
C. It inhibits depolymerisation of microtubules.
D. It inhibits folic acid-dependent thymidine formation.
E. It prevents religation of DNA, leaving strand breaks.
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