How different is mouse growth hormone from human growth hormone? Nucleotide sequences for the two genes are available at the National Center for Biotechnology Information (NCBI) Web site at http://www.ncbi.nlm .nih.gov/. Perform a “Nucleotide” search for accession numbers NM_008117 and NM_000515. Scroll down to look at the mRNA sequences. You may wish to focus on a limited portion of the gene—say, the first 30 nucleotides. Are there differences between the mouse mRNA and the human mRNA? How many differences are there? Now use the genetic code (Table 1) to translate the mRNA sequences into amino acids. Do the differences in mRNA sequences result in different amino acid sequences?
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