HEXA protein domain 115, 153 137 190 224 268 328 357 382 473 508 $29 84 443 Pham Two domains were found on the HEXA sequence by SMART. Active site Glyco hydro_20 Two domains were found in HEXA protein...

what does the Hexa protein domain depict? (in relation with tay sachs disease)

Extracted text: HEXA protein domain 115, 153 137 190 224 268 328 357 382 473 508 $29 84 443 Pham Two domains were found on the HEXA sequence by SMART. Active site Glyco hydro_20 Two domains were found in HEXA protein by Pfam. Glycoside hydrolase family 20, Glycoside hydrolase family 20, catalyticdomain domain 2 ABNORMAL BREAKDOWN OF GM2 GANGLIOSIDE IN TAY-SACHS DISEASE GM2 ganglioside Lysosomes contain enzymes (like Hex A) that break down compounds in the body GM2 ganglioside is broken down GM2 A ganglioside GM2 ganglioside is not broken down In people with Tay-Sachs disease, the Hex A enzymes in the lysosomes do not function properly GM2 ganglioside cannot be broken down properly and accumulates in the brain Figure 8: Schematic view of abnormal breakdown of GM2 ganglioside in Tay-Sachs disease.