Fatigue is not well understood. Some factors that have been proposed to explain the fall in force duringfatigue include: changes in the 'sense of effort', loss of 'central drive', failure of neuromuscular propagation, reduction in calcium release in excitation- contraction coupling, metabolic changes in the muscle, and reduction in muscle blood flow owing to compression of blood vessels.
1. Do your experiments help to decide which factors are important?
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