Explanation about this pathophysiology of Primary aldosteronism The most important factors that predict the pathophysiologic association of hypokalemia with primary aldosteronism are: aldosterone...

Explanation about this pathophysiology of Primary aldosteronism The most important factors that predict the pathophysiologic association of hypokalemia with primary aldosteronism are: aldosterone hypersecretion, which acts on the cortical collecting duct to stimulate potassium secretion into the tubular fluid, thus enhancing renal/urinary potassium wasting; adequate intravascular volume, which enables adequate water delivery (tubular flow rate) to the renal distal convoluted tubules (DCTs) and collecting ducts to enable renal potassium loss; and adequate dietary sodium intake, which, in turn, increases total body potassium and renal/tubular sodium delivery and, thus, enhances renal potassium loss via the countercurrent transport system.