Estradiol and norethindrone (Ortho-Novum) is prescribed for each of the following clients. Which clients would the nurse consider at high risk for an adverse response to this therapy? (Select all that...

Estradiol and norethindrone (Ortho-Novum) is prescribed for each of the following clients. Which clients would the nurse consider at high risk for an adverse response to this therapy? (Select all that apply.)

1. A 38-year-old who is 68.9 kg (152 lb) overweight

2. A 16-year-old athlete with asthma

3. A 22-year-old who smokes two packs of cigarettes per day

4. An 18-year-old with a history of chronic clinical depression

5. A 42-year-old who has delivered four healthy children