Task
Each student will select a unique Disorder and Manipulator, from the list provided, addressing the current Research (R), Diagnosis (D), Treatment (T) and Policy (P) for:
• Part A (10%): ‘Metabolic Disorders’
• Chosen metabolic disorder: Hyperglycerolemia
Assignment Part A – Metabolic Disorders.
Many organisms carry and express genetic mutations that alter the metabolism of the cell, in some cases resulting in disorders, which can be debilitating and/or life threatening. Plants, vertebrates and invertebrates obtain substrates for energy and building blocks, however, some compounds alter energy metabolism (increasing or decreasing rate and/or efficiency).
You should include a brief outline of the analysis method(s) used to detect or confirm the condition, from the topic list provided.
Metabolic Disorders - Hyperglycerolemia Assignment Part A Due Date: 18 Sept (8am) Length: ~1,000 words Rationale The Assignment integrates regulatory aspects of metabolism, enhancing lecture and laboratory activity to enable students to understand the role Research, Diagnostic, Treatment and Policy sectors rely on biochemistry (WIL). Task Each student will select a unique Disorder and Manipulator, from the list provided, addressing the current Research (R), Diagnosis (D), Treatment (T) and Policy (P) for: · Part A (10%): ‘Metabolic Disorders’ · Chosen metabolic disorder: Hyperglycerolemia Assignment Part A – Metabolic Disorders. Many organisms carry and express genetic mutations that alter the metabolism of the cell, in some cases resulting in disorders, which can be debilitating and/or life threatening. Plants, vertebrates and invertebrates obtain substrates for energy and building blocks, however, some compounds alter energy metabolism (increasing or decreasing rate and/or efficiency). You should include a brief outline of the analysis method(s) used to detect or confirm the condition, from the topic list provided. Criteria You will be assessed on the following: The Assignment must use the Headings below and address the following: 1. Overview Identify the name(s), class and structure of the ‘Metabolic Disorder’ (Assignment Part A)) molecule and contextualize the intracellular metabolic biochemical pathways they affect (i.e. Protein, Carbohydrate and/or Lipid). Briefly outline the effect(s) the Disorder (Part A) and Manipulator (Part B) has on the organism locally (i.e. specific cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical steps to produce the Disorder (Part A) and Manipulator (Part B) (i.e. parent molecule, key enzymes & cofactors involved in synthesis) and describe the transport, half-life, receptor activation and fate following action - Disorder (Part A) effect, and Manipulator (Part B) degradation within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate and/or Lipid), the selected Disorder (Part A) and Manipulator (Part B) alters, including key enzymes/cofactors and intermediates directly affected. 2. Research Describe the most recent research (published scientific article(s)) effort pertaining to the Disorder (Part A) and Manipulator (Part B). This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identification of potential therapeutic(s). 3. Diagnosis Identify the disease state(s)/or consequence(s) of the Disorder (Part A) and Manipulator (Part B) that arise if there is a genetic defect (Part A) or chemical perturbation (Part B) in the metabolic /biosynthetic pathway of target cells/tissues. 4. Treatment Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder (Part A) and Manipulator (Part B). Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment. 5. Policy Outline the current policies/legislation (federal, state or international) relevant to the Disorder (Part A) and Manipulator (Part B) (e.g. adverse health outcomes or legislation for therapeutic use). Report Format. Diagrams maybe used (with appropriate references). The report should be in 12pt font, ~1,000 words (for each Part A & Part B), with Vancouver referencing format (labelled as superscript numbers throughout the text and identified in the References, Website(s) should include accession dates). Note: References and diagram/legends are not included in the word count.