.
Download gene sequences for histone H2a contained in accession
numbers Z48612 (S.cerevisiae) and BC001193.1 (H. sapiens) from the
NCBI GenBank database. (In the case of Z48612, use the “Find” function of
your browser to find the annotated gene for H2a, and then click on the “Gene”
link.) Supply these sequences in FASTA format to the alignment server available
at http://www.cmb.usc.edu.
a. Perform a global alignment, using “Single Score” for type of scoring and
default parameters otherwise. Examine the result, and try to identify a
region that you would predict to have the highest-scoring local alignment.
b. Now perform local alignment using the same two sequences and the same
parameters. Were you able to predict the region with high-scoring local
alignment from the global alignment output? Why or why not?