Dopamine is an example of a neurotransmitter that has both excitatory and inhibitory effects in the CNS.Dopamine can have an excitatory effect on a given postsynaptic neuron in the striatum, but an...

Dopamine is an example of a neurotransmitter that has both excitatory and inhibitory effects in the CNS.Dopamine can have an excitatory effect on a given postsynaptic neuron in the striatum, but an inhibitory effect on a postsynaptic neuron in the cortex.The best explanation for this is which of the following?

A. More dopaminergic vesicles are released at the striatal synapse than at the cortical synapse.

B. The receptors on the striatal neuron are ionotropic, and the cortical receptors are metabotropic.

C. The receptors on the striatal neuron have a higher affinity for dopamine than those of the cortical neuron.

D. The ion channels affected in the striatal postsynaptic neuron are different from those in the cortical cell.

E. The receptors at the striatal membrane have greater dopaminergic activation because of lower levels of enzymatic degradation.