Discuss in detail the role of CTLA-4 and PD-1/PD-L1; compare and contrast the two pathways in immunotherapy. Do the two pathways play a complementary and/or synergistic roles? Give an example of 1...

Extracted text: Discuss in detail the role of CTLA-4 and PD-1/PD-L1; compare and contrast the two pathways in immunotherapy. Do the two pathways play a complementary and/or synergistic roles? Give an example of 1 approved drug for each pathway along with information on immunogenicity, route of administration, dosing regimen, and key PK parameters such as half-life and clearance.