Could you use a secretion system to secrete a protein it does not normally secrete? This has been considered in some biotechnology applications to avoid having to lyse bacterial cells. What type of...

Could you use a secretion system to secrete a protein it does not normally secrete? This has been considered in some biotechnology applications to avoid having to lyse bacterial cells. What type of secretion system would you use in the case of a gram-negative bacterium, or is there one? What about a grampositive bacterium? What would you have to do in the way of genetic engineering to make this work? Why might your strategy fail?